Jimmy Kudo is a 17-year-old high school prodigy who frequently helps the police to solve cases. During an investigation, he is attacked by two criminals, codenamed Gin and Vodka, from the syndicate called the Black Organization. They force him to ingest an experimental poison, APTX 4869, which is supposed to kill him, and leave him to die. A rare side-effect of the poison, however, transforms Kudo's body into that of a child instead of killing him.
Adopting the pseudonym Conan Edogawa, Kudo hides his identity to investigate the Black Organization. He intends to pretend to be a child until he can find enough evidence to apprehend the syndicate, after which he can then safely find and administer a cure for his current condition. Edogawa enrolls at Teitan elementary school and forms the Junior Detective League with three other children in his class: Amy Yoshida, Mitch Tsuburaya, and George Kojima. To further cover up his activities, he moves in with his childhood friend Rachel Moore, whose father, Richard, works as a private investigator. Kudo continues to solve criminal cases as Conan, but usually poses as Richard Moore with the help of special gadgets invented by his neighbor and friend, Hiroshi Agasa.
Shiho Miyano, a member of the Black Organization and creator of APTX 4869, tries to leave the syndicate after her sister's murder, but is held captive by them. She attempts to commit suicide by ingesting APTX 4869; however, like Kudo, she is transformed into a child. She manages to escape and enrolls in Conan's school under the pseudonym, Anita Hailey. She joins the Junior Detective League and assists Conan in his investigations on the Black Organization. Conan's quest has led him to help the FBI to plant a CIA agent, Kir, inside the Black Organization as an undercover spy.
In 2007, Aoyama hinted he had the ending planned out but he has no intention of ending the series yet.
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